Medicine

Accelerating ASO therapies from development to execution

.Contending rate of interests.R.S., M.S., H.G. and also A.A.R. are actually coordinators of the 1M1M project. H.G. and A.A.R. are actually panel of supervisors members as well as R.S., M.S. and also A.A.R. are members of the clinical consultatory board of N1C. A.A.R. reveals job by LUMC, which possesses licenses on exon-skipping modern technology, several of which has actually been licensed to BioMarin as well as subsequently sublicensed to Sarepta. As co-inventor of several of these patents, A.A.R. was actually entitled to a portion of aristocracies. A.A.R. further makes known working as impromptu consultant for PTC Rehabs, Sarepta Therapeutics, Regenxbio, Dyne Rehabs, Lilly, BioMarin Pharmaceuticals Inc., Eisai, Entrada, Takeda, Splicesense, Galapagos, Sapreme, Italfarmaco and also Astra Zeneca. In the past 5 years, A.A.R. additionally performed consulting for Alpha Anomeric. A.A.R. also discloses registration of the scientific advisory boards of Eisai, Hybridize Therapies, Silence Therapies, Sarepta Rehabs, Sapreme as well as Mitorx. In the past 5 years, A.A.R. was actually additionally a scientific advisory board member for ProQR. Pay for A.A.R. u00e2 s consulting and advising activities is paid to LUMC. In the past 5 years, LUMC additionally obtained sound speaker honoraria coming from PTC Rehabs, Alnylam Netherlands, Italfarmaco and Pfizer as well as cashing for contract research coming from Sapreme, Eisai, Galapagos, Synaffix and Alpha Anomeric. Project financing is actually acquired from Sarepta Therapeutics and Entrada using unregulated gives. H.G. has absolutely nothing to reveal in connection with the subjects covered in this particular composition. Before 5 years, he has actually likewise acquired consultancy honoraria from UCB. M.S. acquired working as a consultant honoraria coming from Ionis, UCB, Prevail, Orphazyme, Biogen, Servier, Reata, GenOrph, AviadoBio, Biohaven, Zevra, Lilly and also Solaxa previously 5 years, all unassociated to the present composition. R.S. possesses nothing at all to make known relative to the subjects dealt with in this particular document. She has gotten speaker and/or consultancy honoraria or funding payments coming from Abbvie, Bial, STADA and Everpharma previously 5 years.

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